Severe induction of aberrant DNA methylation by nodular gastritis in adults.

Akiko SasakiHideyuki TakeshimaSatoshi YamashitaChikamasa IchitaJun KawachiWataru NaitoYui OhashiChihiro TakeuchiMasahide FukudaYumi FuruichiNobutake YamamichiTakayuki AndoHideki KobaraTohru KoteraTakao ItoiChihiro SumidaAkinobu HamadaKazuya KoizumiToshikazu Ushijima

Published in: Journal of gastroenterology (2024)

Severe aberrant methylation, involving multiple tumor-suppressor genes, was induced in the gastric antrum and body of patients with NG, in accordance with their high gastric cancer risk.

Keyphrases

dna methylation
genome wide
drug induced
early onset
helicobacter pylori
gene expression
high glucose
diabetic rats
helicobacter pylori infection
oxidative stress
endothelial cells