Speech biomarkers in Huntington's disease: A cross-sectional study in pre-symptomatic, prodromal and early manifest stages.

Tomas KoubaWiebke FrankTereza TykalovaAlzbeta MühlbäckJiří KlempířKatrin S LindenbergG Bernhard LandwehrmeyerJan Rusz

Published in: European journal of neurology (2023)

Speech abnormalities in HD are associated with other motor and cognitive deficits and are measurable already in premanifest stages of HD. Therefore, automated speech analysis might represent a quantitative HD biomarker with potential for assessing disease progression.

Keyphrases

hearing loss
machine learning
deep learning
parkinson disease
high resolution
risk factors
risk assessment
human health
mass spectrometry