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Sequential HER2 blockade as effective therapy in chemorefractory, HER2 gene-amplified, RAS wild-type, metastatic colorectal cancer: learning from a clinical case.

Erika MartinelliTeresa TroianiVincenzo SforzaGiulia MartiniClaudia CardonePietro Paolo VitielloDavide CiardielloAnna Maria RachiglioNicola NormannoAndrea Sartore-BianchiSilvia MarsoniAlberto BardelliSalvatore SienaFortunato Ciardiello
Published in: ESMO open (2018)
The clinical case highlights the role of HER2 gene amplification as a key genetic driver of cancer development and progression in mCRC and suggests that sequential HER2 blockade could be a potential therapeutic strategy.
Keyphrases
  • metastatic colorectal cancer
  • wild type
  • genome wide
  • copy number
  • papillary thyroid
  • stem cells
  • squamous cell
  • bone marrow
  • mesenchymal stem cells
  • transcription factor