Sequential HER2 blockade as effective therapy in chemorefractory, HER2 gene-amplified, RAS wild-type, metastatic colorectal cancer: learning from a clinical case.

Erika MartinelliTeresa TroianiVincenzo SforzaGiulia MartiniClaudia CardonePietro Paolo VitielloDavide CiardielloAnna Maria RachiglioNicola NormannoAndrea Sartore-BianchiSilvia MarsoniAlberto BardelliSalvatore SienaFortunato Ciardiello

Published in: ESMO open (2018)

The clinical case highlights the role of HER2 gene amplification as a key genetic driver of cancer development and progression in mCRC and suggests that sequential HER2 blockade could be a potential therapeutic strategy.

Keyphrases

metastatic colorectal cancer
wild type
genome wide
copy number
papillary thyroid
stem cells
squamous cell
bone marrow
mesenchymal stem cells
transcription factor