A genome-wide association study of sodium levels and drug metabolism in an epilepsy cohort treated with carbamazepine and oxcarbazepine.

Bianca BerghuisCaragh StapletonAnja C M SonsmaJanic HulstGerrit-Jan de HaanDick LindhoutRita Demurtasnull nullRoland KrauseChantal DepondtWolfram S KunzFederico ZaraPasquale StrianoJohn CraigPauls AuceAnthony G MarsonHreinn StefanssonTerence J O'BrienMichael R JohnsonGraeme J SillsStefan WolkingHolger LercheSanjay M SisodiyaJosemir W Sander Gianpiero L CavalleriBobby P C KoelemanMark McCormack

Published in: Epilepsia open (2019)

Although we did not detect a genetic predictor of hyponatremia or CBZ metabolism in our cohort, our findings suggest that the determinants of CBZ metabolism are multifactorial.

Keyphrases

genome wide association study
genome wide
emergency department
copy number
atrial fibrillation
adverse drug
drug induced