SIRT1 Coordinates Transcriptional Regulation of Neural Activity and Modulates Depression-Like Behaviors in the Nucleus Accumbens.
Hee-Dae KimJing WeiTanessa CallXiaokuang MaNicole Teru QuintusAlexander J SummersSamantha CarotenutoRoss JohnsonAngel NguyenYuehua CuiJin G ParkShenfeng QiuDeveroux FergusonPublished in: Biological psychiatry (2024)
SIRT1 coordinates excitatory and inhibitory synaptic genes to regulate the GABAergic output tone of D1-MSNs. These findings reveal a novel signaling pathway that has potential for the development of innovative treatments for affective disorders.
Keyphrases
- signaling pathway
- genome wide
- oxidative stress
- ischemia reperfusion injury
- depressive symptoms
- bipolar disorder
- pi k akt
- epithelial mesenchymal transition
- sleep quality
- single cell
- induced apoptosis
- human health
- genome wide identification
- bioinformatics analysis
- risk assessment
- cell proliferation
- genome wide analysis