Want to leave the ER? We offer vesicles, tubules, and tunnels.

Export from the ER is COPII-dependent. However, there is disagreement on the nature of the cargo-containing carriers that exit the ER. Two new studies from Shomron et al. (2021. J. Cell Biol.https://doi.org/10.1083/jcb.201907224) and Weigel et al. (2021. Cell. https://doi.org/10.1016/j.cell.2021.03.035) present a new model, where COPII helps to select secretory cargo but does not coat the carriers leaving the ER.