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Salivary HPV Persistence Following Treatment of Oropharyngeal Squamous Cell Carcinoma.

Alexandra E QuimbyPagona LagiouBibiana PurginaMartin CorstenStephanie Johnson-Obaseki
Published in: The Annals of otology, rhinology, and laryngology (2021)
This study is the first to demonstrate the prevalence of persistent oncogenic HPV DNA in saliva following treatment for HPV + OPSCC. This prevalence appears to be low, despite the fact that persistent HPV infection is a precursor for the development of HPV + OPSCC. This finding raises questions about what factors influence the clearance or persistence of HPV DNA in saliva after treatment for HPV + OPSCC, and may add to our understanding about the longitudinal effects of HPV infection in these cancers.
Keyphrases
  • high grade
  • squamous cell carcinoma
  • cervical cancer screening
  • risk factors
  • radiation therapy
  • transcription factor