The significant role of redox system in myeloid leukemia: from pathogenesis to therapeutic applications.
Natasha Mupeta KawemeShu ZhouGeoffrey Joseph ChangweFuling ZhouPublished in: Biomarker research (2020)
Acute myeloid leukemia remains a daunting challenge to clinicians. The desire to achieve the maximum benefit of chemotherapy but also improve patient outcomes is investigated. ROS generated through several pathways promotes leukemogenesis, drug resistance, and disease relapse. Chemotherapy, the mainstay of treatment, further upregulates ROS levels. Therefore, the addition of an antioxidant to leukemia medical therapy alleviates toxicity and improves patient outcomes.
Keyphrases
- acute myeloid leukemia
- allogeneic hematopoietic stem cell transplantation
- bone marrow
- cell death
- oxidative stress
- dna damage
- locally advanced
- reactive oxygen species
- healthcare
- palliative care
- squamous cell carcinoma
- stem cells
- anti inflammatory
- atomic force microscopy
- dendritic cells
- rectal cancer
- mouse model
- combination therapy
- mass spectrometry
- cell therapy
- high speed