Assessing the Impact of Two-Step Clostridioides difficile Testing at the Healthcare Facility Level.
Nicholas A TurnerJay KrishnanAlicia NelsonChristopher R PolageRonda L CochranLucy FikeDavid T KuharPreeta K KuttyRachel L SnyderDeverick J AndersonPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2023)
Two-step testing is associated with decreased reported incidence of HO-CDI, likely by improving diagnostic specificity. The parallel decrease in C. difficile specific antibiotic use offers indirect reassurance against under-diagnosis of C. difficile infections still requiring treatment by clinician assessment. Similarly, the absence of any significant change in colectomy rates offers indirect reassurance against any rise in fulminant C. difficile requiring surgical management.