Diverse types of genomic evidence converge on alcohol use disorder risk genes.

Yulin DaiRuifeng HuGuangsheng PeiHuiping ZhangZhongming ZhaoPeilin Jia

Published in: Journal of medical genetics (2020)

We characterised multidimensional evidence of genetic, epigenetic and transcriptomic data in AUD. We found that 206 AUD associated genes were highly expressed in liver, brain cerebellum, frontal cortex, hippocampus and pituitary. Our studies provides important insights into the molecular mechanism of AUD and potential target genes for AUD treatment.

Keyphrases

alcohol use disorder
genome wide
dna methylation
functional connectivity
bioinformatics analysis
copy number
resting state
gene expression
genome wide analysis
single cell
white matter
electronic health record
big data
working memory
machine learning
rna seq
deep learning
transcription factor
prefrontal cortex