Synthesis, characterization, and anticancer activity of two mixed ligand copper(ii) complexes by regulating the VEGF/VEGFR2 signaling pathway.

Xiu-Ying QinYa-Nan WangXin-Ping YangJuan-Juan LiangJi-Lin LiuZhao-Hui Luo

Published in: Dalton transactions (Cambridge, England : 2003) (2017)

The single crystals of two novel mixed-ligand copper(ii)-based complexes were obtained and characterized. These complexes can remarkably induce apoptosis, inhibit proliferation, suppress migration and metastasis, and inhibit angiogenesis to inhibit the growth of cervical cancer by down-regulating the expressions of the important proteins FAK, Akt and Erk1/2 or their phosphorylated proteins p-FAK, p-Akt, and p-Erk1/2 downstream of the VEGF/VEGFR2 signaling pathway.

Keyphrases

signaling pathway
vascular endothelial growth factor
pi k akt

endothelial cells
cell cycle arrest
induced apoptosis

epithelial mesenchymal transition
oxidative stress
cell proliferation

cell migration
endoplasmic reticulum stress
cell death