Pyrvinium Pamoate Use in a B cell Acute Lymphoblastic Leukemia Model of the Bone Tumor Microenvironment.

Rajesh R NairDebbie PiktelQuincy A HathawayStephanie L RellickPatrick ThomasPushkar SaralkarKaren H MartinWerner J GeldenhuysJohn M HollanderLaura F Gibson

Published in: Pharmaceutical research (2020)

We have demonstrated that PP is a novel therapeutic lead compound that counteracts the respiratory reprogramming found in refractory ALL cells and can be effectively formulated into a nanoparticle delivery system to target the BTME.

Keyphrases

acute lymphoblastic leukemia
induced apoptosis
cell cycle arrest
bone mineral density
allogeneic hematopoietic stem cell transplantation
endoplasmic reticulum stress
signaling pathway
cell death
soft tissue
oxidative stress
body composition
bone loss
respiratory tract