Immortalization of porcine hepatocytes with a α-1,3-galactosyltransferase knockout background.

Quancheng WangXuan ZhangBo WangGe BaiDengke PanPeijun YangKaishan TaoXiao LiKefeng Dou

Published in: Xenotransplantation (2019)

Two types of immortalized cell lines of porcine hepatocytes with GalT-KO and wild-type backgrounds were successfully established. GalT-KO-hep cells exhibited higher viability and injury resistance against a xenogeneic immune response.

Keyphrases

wild type
immune response
induced apoptosis
liver injury
cell cycle arrest
drug induced
dendritic cells
signaling pathway
oxidative stress