Genetic variation in CYP1A1 and AHRR genes increase the risk of systemic lupus erythematosus and exacerbate disease severity in smoker patients.
Marie Saghaeian JaziSaeed MohammadiMojtaba Zare EbrahimabadSima SedighiNafiseh AbdolahiAlijan TabarraeiYaghoub YazdaniPublished in: Journal of biochemical and molecular toxicology (2021)
Our findings indicated the association of xenobiotic-metabolizing genes (CYP1A1, AHRR) polymorphisms with the susceptibility to SLE and disease severity regarding the smoking background, suggesting the interaction of gene and environmental risk factors in SLE pathogenesis.
Keyphrases
- systemic lupus erythematosus
- disease activity
- genome wide
- risk factors
- end stage renal disease
- genome wide identification
- ejection fraction
- newly diagnosed
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- rheumatoid arthritis
- genome wide analysis
- bioinformatics analysis
- gene expression
- risk assessment
- patient reported outcomes
- climate change