Copper(I) Iodide-Catalyzed Perfluoroalkoxylation Reaction of Alkyl Halides.
Xiong WuBingjun LeWangchuan XiaoJing-Jing WuFanhong WuXiaoyu MaChao LiuPublished in: Organic letters (2024)
We report an efficient perfluoroalkoxylation reaction of alkyl halides catalyzed by copper(I) iodide (CuI), which facilitates the simultaneous activation of both perfluoroalkoxide and alkyl halides. This methodology is tolerant of a wide range of functional groups and eliminates the need for costly metal reagents. The reaction is conducted in a single step under mildly practical conditions.