Human Lung DNA Methylation Quantitative Trait Loci Colocalize with Chronic Obstructive Pulmonary Disease Genome-Wide Association Loci.

Jarrett D MorrowKimberly GlassMichael H ChoCraig P HershVictor Pinto-PlataBartolome CelliNathaniel MarchettiGerard CrinerRaphael BuenoGeorge WashkoAugustine M K ChoiJohn QuackenbushEdwin K SilvermanDawn L DeMeo

Published in: American journal of respiratory and critical care medicine (2019)

Colocalization of mQTL and GWAS loci provides regulatory characterization of significant and subthreshold GWAS findings, supporting a role for genetic control of methylation in COPD pathogenesis.

Keyphrases

genome wide
genome wide association
dna methylation
chronic obstructive pulmonary disease
genome wide association study
lung function
copy number
gene expression
transcription factor
high resolution
mass spectrometry
cystic fibrosis