Screening of predicted synergistic multi-target therapies in glioblastoma identifies new treatment strategies.

Megan HouwelingAnna GiczewskaKulsoom AbdulNinke NieuwenhuisAsli KüçükosmanogluKrzysztof PastuszakRogier C BuijsmanPieter WesselingLaurine WedekindDavid NoskeAnna SupernatDavid BaileyColin WattsThomas WurdingerBart A Westerman

Published in: Neuro-oncology advances (2023)

Overall, we have identified via a high-throughput drug screening several new treatment strategies for GBM. Moreover, an exceptionally strong synergistic interaction was discovered between kinase targeting and apoptosis induction which is suitable for further clinical evaluation as multi-targeted combination therapy.

Keyphrases

combination therapy
cancer therapy
clinical evaluation
high throughput
drug delivery
oxidative stress
cell death
genome wide
endoplasmic reticulum stress
cell cycle arrest
single cell
tyrosine kinase
dna methylation
gene expression
signaling pathway
adverse drug
drug induced