NADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets.
Yixuan ZhangPriya MurugesanKai HuangHua CaiPublished in: Nature reviews. Cardiology (2019)
Reactive oxygen species (ROS)-dependent production of ROS underlies sustained oxidative stress, which has been implicated in the pathogenesis of cardiovascular diseases such as hypertension, aortic aneurysm, hypercholesterolaemia, atherosclerosis, diabetic vascular complications, cardiac ischaemia-reperfusion injury, myocardial infarction, heart failure and cardiac arrhythmias. Interactions between different oxidases or oxidase systems have been intensively investigated for their roles in inducing sustained oxidative stress. In this Review, we discuss the latest data on the pathobiology of each oxidase component, the complex crosstalk between different oxidase components and the consequences of this crosstalk in mediating cardiovascular disease processes, focusing on the central role of particular NADPH oxidase (NOX) isoforms that are activated in specific cardiovascular diseases. An improved understanding of these mechanisms might facilitate the development of novel therapeutic agents targeting these oxidase systems and their interactions, which could be effective in the prevention and treatment of cardiovascular disorders.
Keyphrases
- cardiovascular disease
- reactive oxygen species
- oxidative stress
- heart failure
- left ventricular
- dna damage
- type diabetes
- aortic aneurysm
- cardiovascular risk factors
- cardiovascular events
- cell death
- induced apoptosis
- risk factors
- big data
- blood brain barrier
- brain injury
- atrial fibrillation
- metabolic syndrome
- cerebral ischemia
- diabetic rats
- acute ischemic stroke
- heat stress
- drug delivery
- cancer therapy
- signaling pathway
- coronary artery disease
- subarachnoid hemorrhage
- wound healing
- high speed
- heat shock
- atomic force microscopy
- endoplasmic reticulum stress
- cardiac resynchronization therapy
- replacement therapy