GLP-1 Mediates Regulation of Colonic ACE2 Expression by the Bile Acid Receptor GPBAR1 in Inflammation.

Michele BiagioliSilvia MarchianòRosalinda RoselliCristina Di GiorgioRachele BelliniMartina BordoniEleonora DistruttiBruno CatalanottiAngela ZampellaLuigina GraziosiAnnibale DoniniStefano Fiorucci

Published in: Cells (2022)

ACE2 mRNA expression in the colon of IBD patients and rodent models of colitis is regulated in a TNF-α- and GLP-1-dependent manner. We have identified a GPBAR1/GLP-1 mechanism as a positive modulator of ACE2.

Keyphrases

angiotensin converting enzyme
end stage renal disease
angiotensin ii
ulcerative colitis
newly diagnosed
ejection fraction
chronic kidney disease
rheumatoid arthritis
oxidative stress
peritoneal dialysis
binding protein
patient reported outcomes