miR-494-3p Promotes Erastin-Induced Ferroptosis by Targeting REST to Activate the Interplay between SP1 and ACSL4 in Parkinson's Disease.

Jian Jun MaXiaohuan LiYongyan FanDawei YangQi GuDongsheng LiSiyuan ChenShaopu WuJinhua ZhengHongqi YangXue Li

Published in: Oxidative medicine and cellular longevity (2022)

miR-494-3p significantly promotes ferroptosis by regulating the REST/SP1/ACSL4 axis in PD. Thus, our results open potential therapeutic targets for PD.

Keyphrases

cell death
high glucose
minimally invasive
diabetic rats
drug induced
oxidative stress
risk assessment
climate change
endothelial cells
stress induced