Antibacterial Polysiloxane Polymers and Coatings for Cochlear Implants.
Vlad CozmaIrina RoscaLuminița RădulescuCristian MartuValentin NastasaCristian-Dragos VarganiciElena-Laura UrsuFlorica DorofteiMariana PintealăCarmen RaclesPublished in: Molecules (Basel, Switzerland) (2021)
Within this study, new materials were synthesized and characterized based on polysiloxane modified with different ratios of N-acetyl-l-cysteine (NAC) and crosslinked via UV-assisted thiol-ene addition, in order to obtain efficient membranes able to resist bacterial adherence and biofilm formation. These membranes were subjected to in vitro testing for microbial adherence against S. pneumoniae using standardized tests. WISTAR rats were implanted for 4 weeks with crosslinked siloxane samples without and with NAC. A set of physical characterization methods was employed to assess the chemical structure and morphological aspects of the new synthetized materials before and after contact with the microbiological medium.
Keyphrases
- biofilm formation
- pseudomonas aeruginosa
- transcription factor
- staphylococcus aureus
- candida albicans
- escherichia coli
- hyaluronic acid
- physical activity
- microbial community
- mental health
- adipose tissue
- type diabetes
- genome wide analysis
- metabolic syndrome
- skeletal muscle
- cystic fibrosis
- fluorescent probe
- gestational age
- oxide nanoparticles
- community acquired pneumonia