Biomimetic vascularized adipose-derived mesenchymal stem cells bone-periosteum graft enhances angiogenesis and osteogenesis in a male rabbit spine fusion model.

Tsai-Sheng FuWei-Chuan ChenYing-Chih WangChia-Wei ChangTung-Yi LinChak-Bor Wong

Published in: Bone & joint research (2023)

The tissue-engineered VBPC showed great capability in promoting angiogenesis and osteogenesis in vivo. It may provide a novel approach to create a superior blood supply and nutritional environment to overcome the deficits of current artificial bone graft substitutes.

Keyphrases

bone regeneration
mesenchymal stem cells
bone mineral density
endothelial cells
vascular endothelial growth factor
soft tissue
bone loss
traumatic brain injury
wound healing
postmenopausal women
bone marrow
stem cells