The Potential Use of Ceftazidime-Avibactam Against Carbapenem Resistant Klebsiella pneumoniae Clinical Isolates Harboring Different Carbapenemase Types in a Thai University Hospital.

Worapong NasomsongParnrada NulsopaponDhitiwat ChangpradubManat PongchaidechaSupanun PungcharoenkijkulPiraporn JuntanawiwatWaristha SimsiripornWichai Santimaleeworagun

Published in: Drug design, development and therapy (2021)

CZA exhibited a fairly susceptible rate among the OXA-48-positive isolates in Thailand. The current suggested dose of CZA with prolonged infusion appears appropriate to achieve the pharmacokinetic/pharmacodynamic targets of ceftazidime and avibactam against CRKP carrying blaOXA-48 .

Keyphrases

klebsiella pneumoniae
gram negative
multidrug resistant
acinetobacter baumannii
escherichia coli
drug resistant
low dose
genetic diversity