SP110b Controls Host Immunity and Susceptibility to Tuberculosis.

Jia-Shiun LeuMei-Ling ChenSo-Yi ChangSung-Liang YuChia-Wei LinHsuan WangWan-Chen ChenChin-Hao ChangJann-Yuan WangLi-Na LeeChong-Jen YuIgor KramnikBo-Shiun Yan

Published in: American journal of respiratory and critical care medicine (2017)

These results indicate that SP110b plays a crucial role in shaping the inflammatory milieu that supports host protection during infection by fine-tuning NF-κB activity, suggesting that SP110b may serve as a potential target for host-directed therapy aimed at manipulating host immunity against TB.

Keyphrases

mycobacterium tuberculosis
oxidative stress
stem cells
immune response
emergency department
lps induced
bone marrow
mesenchymal stem cells
pulmonary tuberculosis
cell proliferation
risk assessment
hepatitis c virus
pi k akt
hiv aids
human immunodeficiency virus
smoking cessation
human health