Identification of retinal tau oligomers, citrullinated tau, and other tau isoforms in early and advanced AD and relations to disease status.
Haoshen ShiNazanin MirzaeiYosef KoronyoMiyah R DavisEdward RobinsonGila M BraunOusman JallowAltan RentsendorjV Krishnan RamanujanJustyna Fert-BoberAndrei A KramerovAlexander V LjubimovLon S SchneiderWarren G TourtellotteDebra HawesJulie A SchneiderKeith L BlackRakez KayedMaj-Linda B SelenicaDaniel C LeeDieu-Trang FuchsMaya Koronyo-HamaouiPublished in: bioRxiv : the preprint server for biology (2024)
This study reveals increases in immature and mature retinal tau isoforms in MCI and AD patients, highlighting their relationship with brain pathology and cognition. The data provide strong incentive to further explore retinal tauopathy markers that may be useful for early detection and monitoring of AD staging through noninvasive retinal imaging.
Keyphrases
- optical coherence tomography
- diabetic retinopathy
- cerebrospinal fluid
- optic nerve
- end stage renal disease
- mild cognitive impairment
- newly diagnosed
- ejection fraction
- chronic kidney disease
- white matter
- high resolution
- lymph node
- prognostic factors
- resting state
- pet ct
- machine learning
- big data
- functional connectivity
- photodynamic therapy
- cerebral ischemia