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Disulfiram protects against abdominal aortic aneurysm by ameliorating vascular smooth muscle cells pyroptosis.

Fei LiaoLing WangZhinan WuGuqing LuoYuxuan QianXinjie HeSong DingJun Pu
Published in: Cardiovascular drugs and therapy (2022)
Our findings suggest that disulfiram has a novel protective effect against AAA by inhibiting Ang II-induced VSMCs pyroptosis.
Keyphrases
  • vascular smooth muscle cells
  • abdominal aortic aneurysm
  • angiotensin ii
  • nlrp inflammasome
  • high glucose
  • diabetic rats
  • drug induced
  • endothelial cells
  • oxidative stress
  • stress induced