Magnetic Nanoparticles with Dual Surface Functions-Efficient Carriers for Metalloporphyrin-Catalyzed Drug Metabolite Synthesis in Batch and Continuous-Flow Reactors.
László PoppeBalázs DecsiRéka KrammerGergő DargóFerenc EnderJános MizseiRóbert BerkeczBenjámin GyarmatiAndrás SzilágyiRóbert TőtősCsaba PaizsLászló PoppeGyörgy T BaloghPublished in: Nanomaterials (Basel, Switzerland) (2020)
The dual functionalization of magnetic nanoparticles with inert (methyl) and reactive (aminopropyl) groups enables efficient immobilization of synthetic metalloporphyrins (such as 5,10,15,20-tetrakis(2,3,4,5,6-pentafluorophenyl)iron(II) porphyrin and 5,10,15,20-tetrakis-(4-sulfonatophenyl)iron(II) porphyrin) via covalent or ionic interactions. The proportion of reactive function on the surface has significant effect on the biomimetic activity of metalloporphyrins. The optimized magnetic nanocatalyst containing porphyrin was successfully applied for biomimetic oxidation of antihypertensive drug Amlodipine in batch and continuous-flow reactors as well.
Keyphrases
- magnetic nanoparticles
- photodynamic therapy
- anaerobic digestion
- electron transfer
- metal organic framework
- energy transfer
- blood pressure
- hypertensive patients
- iron deficiency
- adverse drug
- room temperature
- drug induced
- ionic liquid
- hydrogen peroxide
- molecularly imprinted
- emergency department
- solid state
- arterial hypertension