Synthesis of Carbazoles by a Diverted Bischler-Napieralski Cascade Reaction.
Matteo FaltraccoSaid Ortega-RosalesElwin JanssenRăzvan C CiocChristophe M L Vande VeldeEelco RuijterPublished in: Organic letters (2021)
An unforeseen twist in a seemingly trivial Bischler-Napieralski reaction led to the selective formation of an unexpected carbazole product. The reaction proved to be general, providing access to a range of diversely substituted carbazoles from readily available substrates. Judicious variation of substituents revealed a complex cascade mechanism comprising no less than 10 elementary steps, that could be diverted in multiple ways toward various other carbazole derivatives.