Inflammation in Children with CKD Linked to Gut Dysbiosis and Metabolite Imbalance.
Johannes HolleHendrik BartolomaeusUlrike LoeberFelix BehrensTheda U P BartolomaeusHarithaa AnandakumarMoritz I WimmerDai Long VuMathias KuhringUlrike BrüningAndras MaifeldSabrina GeisbergerStefan KempaFabian SchumacherBurkhard KleuserPhilip BuflerUwe QuerfeldStefanie KitschkeDenise EnglerLeonard D KuhrtOliver DrechselKai Uwe EckardtSofia K ForslundAndrea ThürmerVictoria McParlandJennifer A KirwanNicola WilckDominik MüllerPublished in: Journal of the American Society of Nephrology : JASN (2022)
Gut barrier dysfunction and microbial metabolite imbalance apparently mediate the proinflammatory immune phenotype, thereby driving the susceptibility to cardiovascular disease. The data highlight the importance of the microbiota-immune axis in CKD, irrespective of confounding comorbidities.