Single-Dose Toxicity Study on ML171, a Selective NOX1 Inhibitor, in Mice.
Se-Hyun OhJi-Sun AhnEun-Joo OhYou-Jin KimJu-Min YookJeong-Hoon LimHee-Yeon JungJi-Young ChoiChan-Duck KimSun-Hee ParkYong-Lim KimJang Hee ChoPublished in: BioMed research international (2021)
Our results indicate that the lethal IP injection dose of ML171 is 500 mg/kg for both males and females. Mortality were not observed for lower doses of ML171. The safe dose of single IP ML171 in ICR mice was 250 mg/kg or less. Further studies are needed to confirm the safety of ML171 in the human body.