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Genetic and Functional Evaluation of the Role of FOXO1 in Antituberculosis Drug-Induced Hepatotoxicity.

Jingwei ZhangLin JiaoJiajia SongTao WuHao BaiTangyuheng LiuZhenzhen ZhaoXuejiao HuBinwu Ying
Published in: Evidence-based complementary and alternative medicine : eCAM (2021)
Variants of the rs4435111 and rs2755237 loci in the FOXO1 gene were associated with susceptibility to ATDH. Coadministration of INH/RIF promoted the transfer of FOXO1 from the cytoplasm to the nucleus, but the functional significance of its nuclear translocation requires further verification.
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