Genetic and Functional Evaluation of the Role of FOXO1 in Antituberculosis Drug-Induced Hepatotoxicity.

Jingwei Zhang Lin Jiao Jiajia Song Tao Wu Hao Bai Tangyuheng LiuZhenzhen ZhaoXuejiao Hu Binwu Ying

Published in: Evidence-based complementary and alternative medicine : eCAM (2021)

Variants of the rs4435111 and rs2755237 loci in the FOXO1 gene were associated with susceptibility to ATDH. Coadministration of INH/RIF promoted the transfer of FOXO1 from the cytoplasm to the nucleus, but the functional significance of its nuclear translocation requires further verification.

Keyphrases

drug induced
liver injury
genome wide
copy number
transcription factor
pi k akt
signaling pathway
dna methylation
genome wide identification
gene expression
cell proliferation
genome wide association study
electron transfer