Genetic and Functional Evaluation of the Role of FOXO1 in Antituberculosis Drug-Induced Hepatotoxicity.
Jingwei ZhangLin JiaoJiajia SongTao WuHao BaiTangyuheng LiuZhenzhen ZhaoXuejiao HuBinwu YingPublished in: Evidence-based complementary and alternative medicine : eCAM (2021)
Variants of the rs4435111 and rs2755237 loci in the FOXO1 gene were associated with susceptibility to ATDH. Coadministration of INH/RIF promoted the transfer of FOXO1 from the cytoplasm to the nucleus, but the functional significance of its nuclear translocation requires further verification.