RORγt inhibition ameliorates IL-23 driven experimental Psoriatic Arthritis by predominantly modulating γδ-T cells.

Céline MortierEric GraceyJulie CoudenysTeddy ManuelloTine DecruyMargaux MaelegheerFlore StappersElisabeth GilisDjoere GaublommeLuc Van HoorebekeSophie Van WeldenCatherine AmblerMartin HegenPeter SymanowiczStefan SteynGabriel BersteinDirk ElewautKoen Venken

Published in: Rheumatology (Oxford, England) (2023)

RORγt-blockade shows therapeutic efficacy in a preclinical PsA model with protection towards extra-musculoskeletal manifestations, reflected by a clear attenuation of type 17 cytokine responses by γδ-T cells and Th17 cells.

Keyphrases

cell proliferation
induced apoptosis
prostate cancer
cell cycle arrest
signaling pathway
endoplasmic reticulum stress
mouse model
radical prostatectomy
cell therapy
oxidative stress
stem cells
mesenchymal stem cells