Cell of origin in diffuse large B-cell lymphoma in systemic lupus erythematosus: molecular and clinical factors associated with survival.
Basile Tessier-CloutierDavid Dw TwaEva BaecklundRandy GascoyneNathalie A JohnsonCarin BacklinDiane L KamenAnn E ClarkeRosalind Ramsey-GoldmanJennifer Lf LeePedro FarinhaSasha BernatskyPublished in: Lupus science & medicine (2019)
We present novel data characterising DLBCL in SLE. Sixty per cent of the DLBCL in patients with SLE were non-GCB. The nodal and extranodal distribution in SLE was similar to what is known in the general population, but extranodal disease occurred more often with short SLE duration and was associated with longer overall survival. More research on cancer in SLE is the key to further understanding the complex interplay between cancer and the immune system.
Keyphrases
- systemic lupus erythematosus
- diffuse large b cell lymphoma
- disease activity
- papillary thyroid
- epstein barr virus
- rheumatoid arthritis
- squamous cell
- single cell
- lymph node
- squamous cell carcinoma
- big data
- cell therapy
- lymph node metastasis
- electronic health record
- radiation therapy
- stem cells
- young adults
- machine learning
- single molecule
- data analysis
- rectal cancer