Design, synthesis and applications of NIR-emissive scaffolds of diketopyrrolopyrrole-aza-BODIPY hybrids.
Lingyun WangHui DingZihao XiongXueguang RanHao TangDerong CaoPublished in: Chemical communications (Cambridge, England) (2022)
Herein, we report a facile synthetic method towards diketopyrrolopyrrole-aza-BODIPY hybrids by a two-step strategy. The three resulting fluorophores (LAB-TH4 ∼ LAB-TH6) showed absorption maxima up to 637 nm with molar extinction coefficients ( ε ) up to 32 300 M -1 cm -1 and emission maxima at 661 nm with a fluorescence quantum yield of 25.2% in solution. Due to good biocompatibility and strong ROS generation ability, they are useful fluorophores for bioimaging and photodynamic therapy (PDT). In addition, as a useful scaffold, a novel NIR-emissive conjugated polymer can be constructed by further bromination and Suzuki coupling polymerization.
Keyphrases
- photodynamic therapy
- fluorescent probe
- tissue engineering
- living cells
- single molecule
- fluorescence imaging
- energy transfer
- quantum dots
- light emitting
- wastewater treatment
- cell death
- molecular dynamics
- dna damage
- reactive oxygen species
- solid state
- room temperature
- highly efficient
- gold nanoparticles
- visible light
- electron transfer