A new mechanism for a familiar mutation - bovine DGAT1 K232A modulates gene expression through multi-junction exon splice enhancement.

Tania FinkThomas John LopdellKathryn TipladyRenee HandleyThomas J J JohnsonRichard J SpelmanStephen R DavisRussell G SnellMathew D Littlejohn

Published in: BMC genomics (2020)

The relative contributions of the enzymatic and transcription-based mechanisms now attributed to K232A remain unclear; however, these results suggest that transcriptional impacts contribute to the diversity of lactation effects observed at the DGAT1 locus.

Keyphrases

gene expression
transcription factor
dna methylation
human milk
hydrogen peroxide
oxidative stress
heat shock protein