Efficacy of PI3K/AKT/mTOR pathway inhibitors for the treatment of advanced solid cancers: A literature-based meta-analysis of 46 randomised control trials.

Xuan LiDanian DaiBo ChenHailin TangXiaoming XieWeidong Wei

Published in: PloS one (2018)

Our meta-analysis results suggest that the addition of the PI3K pathway inhibitors to the therapy regiment for advanced solid tumours significantly improves PFS. The way that patients are selected to receive the PI3K pathway inhibitors might be more meaningful in the future.

Keyphrases

systematic review
end stage renal disease
meta analyses
clinical trial
newly diagnosed
ejection fraction
chronic kidney disease
open label
peritoneal dialysis
prognostic factors
study protocol
placebo controlled