1,25(OH)2D3 and dexamethasone additively suppress synovial fibroblast activation by CCR6+ T helper memory cells and enhance the effect of tumor necrosis factor alpha blockade.

Wendy DankersClaudia González-LealNadine DavelaarPatrick S AsmawidjajaAdriana M C MusJohanna M W HazesEdgar M ColinErik Lubberts

Published in: Arthritis research & therapy (2018)

This study suggests that 1,25(OH)2D3 and DEX additively inhibit synovial inflammation through targeting predominantly CCR6+ memTh cells and RASF, respectively. Furthermore, low doses of DEX and 1,25(OH)2D3 enhance the effect of TNFα blockade in inhibiting RASF activation, thus providing a basis to improve RA treatment.

Keyphrases

induced apoptosis
rheumatoid arthritis
cell cycle arrest
dendritic cells
regulatory t cells
oxidative stress
signaling pathway
endoplasmic reticulum stress
cell death
high dose
pi k akt
systemic lupus erythematosus
drug delivery
cancer therapy
african american
interstitial lung disease