Single-cell analysis of immune and stroma cell remodeling in clear cell renal cell carcinoma primary tumors and bone metastatic lesions.
Shenglin MeiAdele M AlchahinIoanna TseaYoumna KfouryTaghreed HirzNathan Elias JeffriesTing ZhaoYanxin XuHanyu ZhangHirak SarkarShulin WuAlexander O SubtelnyJohn Inge JohnsenYida ZhangKeyan SalariChin-Lee WuMark A RandolphDavid T ScaddenDouglas M DahlJohn ShinPeter V KharchenkoPhilip J SaylorDavid B SykesNinib BaryawnoPublished in: Genome medicine (2024)
These results provide a comprehensive analysis of the bone marrow niche in the setting of human metastatic cancer and highlight potential therapeutic targets for both cell populations and communication channels.
Keyphrases
- single cell
- bone marrow
- rna seq
- squamous cell carcinoma
- small cell lung cancer
- cell therapy
- endothelial cells
- papillary thyroid
- high throughput
- mesenchymal stem cells
- stem cells
- bone mineral density
- risk assessment
- body composition
- induced pluripotent stem cells
- climate change
- postmenopausal women
- lymph node metastasis