Cartilage-binding antibodies initiate joint inflammation and promote chronic erosive arthritis.

Yanpeng LiDongmei TongPeibin LiangErik LönnblomJohan ViljanenBingze XuKutty Selva NandakumarRickard Holmdahl

Published in: Arthritis research & therapy (2020)

The new mouse model for RA induced with cartilage antibodies allows studies of chronic development of arthritis and epitope spreading of the autoimmune response and bone erosion.

Keyphrases

rheumatoid arthritis
mouse model
drug induced
oxidative stress
extracellular matrix
multiple sclerosis
high glucose
diabetic rats
bone mineral density
disease activity
ankylosing spondylitis
transcription factor
dna binding
case control
body composition
idiopathic pulmonary fibrosis
bone regeneration