In this issue of Cell Stem Cell, Yoo et al. 1 report that replacing Trem2 knockout microglia with Trem2 wild-type microglia-like cells derived from systemically transplanted hematopoietic cells rectifies microglial dysfunction in a mouse model of amyloidosis. These findings highlight the potential of microglia replacement therapy for Alzheimer's disease treatment.
Keyphrases
- inflammatory response
- neuropathic pain
- wild type
- stem cells
- mouse model
- lipopolysaccharide induced
- cognitive decline
- induced apoptosis
- lps induced
- spinal cord injury
- spinal cord
- bone marrow
- cell therapy
- cell cycle arrest
- mesenchymal stem cells
- cell death
- cell proliferation
- human health
- combination therapy
- smoking cessation