Protective effects of coffee consumption following liver transplantation for hepatocellular carcinoma in cirrhosis.

Georg J WiltbergerYan WuUndine LangeHans-Michael HauElliot TapperFelix KrenzienGeorgi AtanasovChristian BenzingLinda FeldbrüggeEva CsizmadiaJohannes BroschewitzMichael BartelsDaniel SeehoferSven JonasThomas BergPhillip HesselRudi AscherlUlf P NeumannJohann PratschkeSimon C RobsonMoritz Schmelzle

Published in: Alimentary pharmacology & therapeutics (2020)

Coffee consumption is associated with a decreased risk of HCC recurrence and provides for increased survival following OLT. We suggest that these results might be, at least in part, associated with the antagonist activity of caffeine on adenosine-A2AR mediated growth-promoting effects on HCC cells.

Keyphrases

induced apoptosis
free survival
cell cycle arrest
endoplasmic reticulum stress
cell death
oxidative stress