DOT1L Epigenetically Regulates Autophagy and Mitochondria Fusion in Cell Lines of Renal Cancer.

Yanguang HouJiachen LiuShiyu HuangLei WangJuncheng HuXiuheng Liu

Published in: Technology in cancer research & treatment (2023)

We revealed the essential role of Farnesoid X receptor in regulating DOT1L-induced autophagy and mitochondrial fission through the AMP-activated protein kinase/mammalian target of rapamycin pathway in cell lines of renal cancer, which may provide new insights into the pathogenesis of renal cell cancer.

Keyphrases

papillary thyroid
protein kinase
cell death
squamous cell
signaling pathway
single cell
lymph node metastasis
squamous cell carcinoma
stem cells
cell therapy
childhood cancer
drug induced
stress induced
energy transfer