Differential Vulnerability of Hippocampal Subfields to Amyloid and Tau Deposition in the Lewy Body Diseases.
Rong YeAnna E GoodheartJoseph J LocascioErin PeterecMichael ProperziEmma G ThibaultErin ChubaKeith A JohnsonMichael J BrickhouseAlexandra TouroutoglouJohn H GrowdonBradford C DickersonStephen N GompertsPublished in: Neurology (2024)
In LBD, volume loss in hippocampal output subregions-particularly the subiculum-is associated with functional cognition and AD-related deposits. Tau deposition appears to accelerate subiculum and CA1 atrophy, whereas Aβ does not. Subiculum volume may have value as a biomarker of AD copathology-mediated neurodegeneration and disease progression.