A comprehensive gene-centric pleiotropic association analysis for 14 psychiatric disorders with GWAS summary statistics.

Haojie LuJiahao QiaoZhonghe ShaoTing WangShuiping HuangPing Zeng

Published in: BMC medicine (2021)

Our study is among the first large-scale effort to characterize gene-level pleiotropy among a greatly expanded set of psychiatric disorders and provides important insight into shared genetic etiology underlying these disorders. The findings would inform psychiatric nosology, identify potential neurobiological mechanisms predisposing to specific clinical presentations, and pave the way to effective drug targets for clinical treatment.

Keyphrases

genome wide
copy number
mental health
emergency department
gene expression
risk assessment
transcription factor
data analysis