PI3K inhibitor treatment ameliorates the glucocorticoid insensitivity of PBMCs in severe asthma.

Jing BiZhihui MinHonglei YuanZhilong JiangRuolin MaoTao ZhuChunfang LiuYuzhen ZengJuan SongChunling DuZhihong Chen

Published in: Clinical and translational medicine (2020)

This study demonstrates that PI3K inhibitors ameliorate GC insensitivity in severe asthma by restoring HDAC2 activity and inhibiting the phosphorylation of nuclear signaling transcription factors.

Keyphrases

transcription factor
signaling pathway
mouse model
mass spectrometry
dna binding
high resolution
gas chromatography