Neurite orientation and dispersion density imaging (NODDI) detects cortical and corticospinal tract degeneration in ALS.

Rebecca J BroadMatt C GabelNicholas G DowellDavid J SchwartzmanAnil K SethHui ZhangDaniel C AlexanderMara CercignaniP Nigel Leigh

Published in: Journal of neurology, neurosurgery, and psychiatry (2018)

NODDI demonstrates that axonal loss within the CST is a core feature of degeneration in ALS. This is the main factor contributing to the altered diffusivity profile detected using DTI. NODDI also identified dendritic alterations within the PCG, suggesting microstructural cortical dendritic changes occur together with CST axonal damage.

Keyphrases

spinal cord injury
white matter
amyotrophic lateral sclerosis
high resolution
machine learning
oxidative stress
optic nerve
deep learning
multiple sclerosis