Pain and depression are associated with both physical and mental fatigue independently of comorbidities and medications in primary Sjögren's syndrome.
Kate L HackettKristen DaviesJessica TarnRebecca BraggBen HargreavesSamira MiyamotoPeter McMeekinSheryl MitchellSimon BowmanElizabeth J PriceColin PeasePaul EmeryJacqueline AndrewsPeter LanyonJohn HunterMonica GuptaMichele BombardieriNurhan SutcliffeCostantino PitzalisJohn McLarenAnnie CooperMarian ReganIan GilesDavid IsenbergSaravan VadiveluDavid CoadyBhaskar DasguptaNeil McHughSteven Young-MinRobert John MootsNagui GendiMohammed AkilBridget GriffithsDennis William LendremWan-Fai NgPublished in: RMD open (2019)
These findings support further research and clinical interventions targeting pain, dryness, depression and sleep to improve fatigue in patients with pSS.This finding is robust to both the effect of other comorbidities associated with fatigue and medications associated with drowsiness.