rhBMP-2 induces terminal differentiation of human bone marrow mesenchymal stromal cells only by synergizing with other signals.
Neda KathamiCarolina Moreno-VicentePablo MartínJhonatan A Vergara-ArceRaquel Ruiz-HernándezDaniela GerovskaAna M AransayMarcos J Araúzo-BravoSandra Camarero-EspinosaAnder AbarrategiPublished in: Stem cell research & therapy (2024)
Altogether, our data indicate that rhBMP-2 alone is unable to induce in vitro osteogenic terminal differentiation of hBM-MSCs, but synergizes with other signals to potentiate multiple differentiation phenotypes. Therefore, rhBMP-2 triggers on hBM-MSCs different specific phenotype differentiation depending on the signalling environment.