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rhBMP-2 induces terminal differentiation of human bone marrow mesenchymal stromal cells only by synergizing with other signals.

Neda KathamiCarolina Moreno-VicentePablo MartínJhonatan A Vergara-ArceRaquel Ruiz-HernándezDaniela GerovskaAna M AransayMarcos J Araúzo-BravoSandra Camarero-EspinosaAnder Abarrategi
Published in: Stem cell research & therapy (2024)
Altogether, our data indicate that rhBMP-2 alone is unable to induce in vitro osteogenic terminal differentiation of hBM-MSCs, but synergizes with other signals to potentiate multiple differentiation phenotypes. Therefore, rhBMP-2 triggers on hBM-MSCs different specific phenotype differentiation depending on the signalling environment.
Keyphrases
  • bone marrow
  • mesenchymal stem cells
  • umbilical cord
  • endothelial cells
  • electronic health record
  • big data
  • machine learning
  • deep learning
  • induced pluripotent stem cells