Unravelling the Protective Effects of Emodin Against Cyclophosphamide Induced Gonadotoxicity in Male Wistar Rats.

Yinhua WangZhaoling ZouAmit Jaisi Opeyemi Joshua Olatunji

Published in: Drug design, development and therapy (2021)

This study provides a basis for the potential use of EMD in counteracting chemotherapy induced testicular toxicity. The results further suggest that EMD testicular protective effects in CP-treated rats may be mediated through its modulatory role on oxidative stress and inflammation.

Keyphrases

oxidative stress
diabetic rats
chemotherapy induced
germ cell
dna damage
ischemia reperfusion injury
induced apoptosis
high glucose
high dose
drug induced
risk assessment
climate change
newly diagnosed
heat shock
endoplasmic reticulum stress