Mitochondrial sourcing of interferogenic ligands and an autoantigen in human obesity-associated metaflammation.

Amrit Raj GhoshPurbita BandopadhyayJit SarkarShashi KhannaTamonas ChaudhuriOm TantiaPartha ChakrabartiDipyaman Ganguly

Published in: Obesity (Silver Spring, Md.) (2023)

Interferogenic ligands and an autoantigen can be sourced from dysfunctional mitochondria in VAT of humans with obesity. Further therapeutic and prognostic potential for this immune mechanism in obesity warrants exploration.

Keyphrases

insulin resistance
metabolic syndrome
weight loss
high fat diet induced
type diabetes
weight gain
oxidative stress
cell death
risk assessment
body mass index